For research use only. Not for human consumption.
KPV
For topical application only.
KPV is a tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH) that is primarily studied for its anti-inflammatory and antimicrobial properties. In laboratory research, it is used to investigate intracellular signaling, cytokine regulation, and mucosal or dermal healing processes.
Technical Specifications
| Feature | Details |
|---|---|
| Purity | 99% (Validated by HPLC) |
| Concentration | 10mg per vial |
| Molecular Formula | C₁₄H₂₆N₄O₄ |
| Molecular Weight | ~314.38 g/mol |
| Sequence | Lys-Pro-Val |
| Physical Form | White lyophilized powder |
Key Product Features
- Targeted Immunomodulation: Inhibits NF-κB signaling, reducing the production of pro-inflammatory cytokines.
- COA Verified: Each batch undergoes HPLC and Mass Spectrometry testing to ensure ≥99% purity for reliable laboratory data.
- Advanced Stability: Small tripeptide structure provides enhanced stability and solubility for in vitro experiments.
- Laboratory Use Focused: Designed strictly for analytical, biochemical, and in vitro research applications.
Mechanism of Action (Research Context)
KPV is investigated for its intracellular anti-inflammatory and regenerative properties:
- Cytokine Suppression: Reduces expression of IL-6, IL-8, and TNF-α, helping to modulate inflammatory responses.
- Mucosal & Gut Research: Explored for reducing intestinal inflammation and maintaining barrier integrity in models of IBD and colitis.
- Wound Healing & Antimicrobial Activity: Enhances tissue repair while exerting antimicrobial effects against pathogens such as Staphylococcus aureus.
Research FAQ
How does KPV differ from α-MSH in research?
KPV represents the 11–13 fragment of α-MSH and lacks the amino acid sequence required to bind MC1R, which mediates pigmentation. This allows studies of anti-inflammatory effects independently of melanotropic activity.
What are the storage requirements?
- Lyophilized Powder: 2–8°C for short-term use, -20°C for long-term storage (up to 24 months).
- Reconstituted Solution: Keep refrigerated and use within 21 days.
What is the recommended reconstitution procedure?
- Solvent: Bacteriostatic Water or Sterile PBS
- Standard Dilution:
- 2mL solvent for a 5mg/mL solution
- 1mL solvent for a 10mg/mL solution
- Handling: Gently roll until fully dissolved. KPV dissolves quickly and is less prone to denaturation than larger peptides.
What research applications is KPV used for?
Used in studies of IBD, dermatological inflammation (e.g., psoriasis, eczema), and general systemic inflammation models.
Compliance Notice
For research use only. Not for human consumption.
This product is intended strictly for laboratory research purposes.
For topical application only.
Not for human or animal consumption, injection, or ingestion.
